Adam K. Pack, Ph.D.
Biography
I grew up in Syracuse New York (as a native, I can be seen in short sleeves later in the season than some other faculty). A lifelong biologist at heart, I got my BS in biology at SUNY-Binghamton (now known as Binghamton University) and swam for the Binghamton Colonials (now known as the Bearcats). After a few years coaching swimming and water polo, I entered graduate school at SUNY-Health Science Center at Syracuse (now known as Upstate Medical University) in the department of anatomy and cell biology (now known as the department of cellular and developmental biology), where I got my Ph.D. studying hearing loss in the mammalian hearing organ (still known as the organ of Corti).
My research involves mechanosensory organs (organs that "translate" mechanical vibrations into nerve impulses).
Some of these receptors are in skin and other parts of the body (touch receptors). My colleagues and I are currently exploring the role of glia (so-called ‘supporting cells’ in these receptors, and how they are arranged in the body to give a maximum amount of information to the brain.
Some of these receptors are in the inner ear of mammals -- the vestibular system (balance) and the organ of Corti in the cochlea (hearing). Both of these organs use specialized sensory cells called "hair cells" to detect vibration or movement, and specialized "supporting cells" to hold the hair cells in place. In the vestibular system, some hair cells need to be destroyed in one kind of treatment for Meniéres disease, a severe balance and hearing disorder. After this treatment, the supporting cells may divide and replace the hair cells, with accompanying return of symptoms. Two focuses of my research in the vestibular system are how to destroy vestibular hair cells without cochlear hair cells using aminoglycoside antibiotics, and determining if in fact supporting cells are a source of new hair cells in the vestibular system following this treatment. In the auditory system, hair cells are not ever replaced after loss, so prevention of noise-induced hearing loss is paramount. In a phenomenon called "conditioning", a previous noise exposure can render the auditory system resistant to hearing loss from a later, louder sound. One component of this resistance appears to be modification of the tubulin cytoskeleton in the supporting cells of the organ of Corti, which may render the organ less stiff, and therefore less susceptible to damage. The mechanisms of these modifications, their timecourse, and their relation to resistance to hearing loss are all questions remaining to be answered in my lab. Some of this research takes place on the Utica College campus, and some takes place at the Institute for Sensory Research in Syracuse.
Opportunities for Student Research and Collaboration
Histology -- both immunocytochemistry and cell counting -- on plastic-embedded specimens will take place on the Utica campus, and students are welcome to participate. Electrophysiology, specimen preparation, noise exposure, surgery, and western blotting/cell biology will take place at both Utica College, and the Institute for Sensory Research in Syracuse, primarily during the summers. Some limited funding may be available for summer study. My attitude towards students in research is the same as that of my late advisor, Dr. Norma Slepecky. You learn by doing, and there is no facet of research a dedicated undergraduate student cannot learn successfully. Any part of these projects we can get funding for you to complete is open to your participation.
Education
BS in biology at SUNY-Binghamton (Binghamton University)
Ph.D. in anatomy and cell biology, SUNY-Health Science Center at Syracuse (Upstate Medical University)
Research
Pack AK, Pawson LJ. Neuroglial Modulation in Peripheral Sensory Systems. Neuroscientist 2010;(forthcoming August 2010)
Pawson L, Prestia LT, Mahoney GK, Güçlü B, Cox PJ, Pack AK. GABAergic/glutamatergic-glial/neuronal interaction contributes to rapid adaptation in pacinian corpuscles. J. Neurosci 2009 Mar;29(9):2695-2705.
Suryadevara AC, Wanamaker HH, Pack A. The effects of sound conditioning on gentamicin-induced vestibulocochlear toxicity in gerbils. Laryngoscope 2009 Jun;119(6):1166-1170.
Güçlü B, Mahoney GK, Pawson LJ, Pack AK, Smith RL, Bolanowski SJ. Localization of Merkel cells in the monkey skin: an anatomical model. Somatosens Mot Res 2008;25(2):123-38.
Pawson L, Checkosky CM, Pack AK, Bolanowski SJ. Mesenteric and tactile Pacinian corpuscles are anatomically and physiologically comparable. Somatosens Mot Res 2008 Sep;25(3):194-206.
Pawson L, Pack AK, Bolanowski SJ. Possible glutaminergic interaction between the capsule and neurite of Pacinian corpuscles. Somatosens Mot Res 2007;24(1-2):85-95.
Awards and Recognition
Harold T. Clark Jr. Award 2011
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